Ampalaya has the most documented scientific reports that cite its blood sugar-lowering benefit. Research worldwide since the 1960s cites
the plant’s key compounds, notably polypeptide-P, a plant insulin known
to lower blood sugar levels. The plant's insulin-like benefits have long-been enjoyed by many diabetics, who include the fruit as part of their daily diet, either eaten as a vegetable or taken as a tea. With the traditional use supported by modern scientific validation of the plant's benefits, the Ampalaya is the single most promising plant/herb for diabetes today.

Rich in potassium, iron and beta-carotene and other nutrients, Ampalaya can be found in many Asian vegetable dishes. But aside from its role as a healthy food, the herb is especially valued by diabetics for its known anti-diabetes properties. The traditional remedy is made by pounding the raw fruits into a bitter liquid, or by boiling the leaves and fruits for a few minutes, the resulting water then drank as a herbal tea.